Article

Mechanisms of blood homeostasis: lineage tracking and a neutral model of cell populations in rhesus macaque

2015-10-03

Abstract excerpt

How a potentially diverse population of hematopoietic stem cells (HSCs) differentiates and proliferates to supply more than 10 11 mature blood cells every day in humans remains a key biological question. We investigated this process by quantitatively analyzing the clonal structure of peripheral blood that is generated by a population of transplanted lentivirus-marked HSCs in myeloablated rhesus macaques. Each tr...

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Literature Corpus work: f822e65a-c7b8-5caa-be34-64f0afe177f4
DOI: 10.1101/028167

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