Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The impact of aging on primate hematopoiesis as interrogated by clonal tracking

2 Jan 2018

Abstract excerpt

Age-associated changes in hematopoietic stem and progenitor cells (HSPCs) have been carefully documented in mouse models but poorly characterized in primates and humans. To investigate clinically relevant aspects of hematopoietic aging, we compared the clonal output of thousands of genetically barcoded HSPCs in aged vs young macaques after autologous transplantation. Aged macaques showed delayed emergence of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Hematopoietic Stem Cell Transplantation
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29295845
DOI: 10.1182/blood-2017-08-802033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The impact of aging on primate hematopoiesis as interrogated by clonal trackingPMID 29295845Read ↗

Quantitative stability of hematopoietic stem and progenitor cell clonal output in rhesus macaques receiving transplantsSemantic proximity Read ↗

The global clonal complexity of the murine blood system declines throughout life and after serial transplantationSemantic proximity Read ↗

Long-term tracking of haematopoietic clonal dynamics and mutations in non-human primate undergoing transplantation of lentivirally barcoded haematopoietic stem and progenitor cells.Semantic proximity Read ↗

Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell CompartmentSemantic proximity Read ↗

Hand in hand: intrinsic and extrinsic drivers of aging and clonal hematopoiesis.Semantic proximity Read ↗

Age-related clonal hematopoiesis.Semantic proximity Read ↗

Molecular and phenotypic blueprint of the hematopoietic compartment reveals proliferation stress as a driver of age-associated human stem cell dysfunctionsSemantic proximity Read ↗

Aging, clonal hematopoiesis and preleukemia: not just bad luck?Semantic proximity Read ↗

Tracking Human HSCs and MPPs in Mice Reveals Distinct Clonal Dynamics and Responses to Pre-transplant ConditioningSemantic proximity Read ↗

Clonal dynamics of haematopoiesis across the human lifespanSemantic proximity Read ↗

Clonal dynamics of haematopoiesis across the human lifespanSemantic proximity Read ↗

Clonal dynamics and somatic evolution of haematopoiesis in mouseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.