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Quantitative stability of hematopoietic stem and progenitor cell clonal output in rhesus macaques receiving transplants

13 Jan 2017

Abstract excerpt

Autologous transplantation of hematopoietic stem and progenitor cells lentivirally labeled with unique oligonucleotide barcodes flanked by sequencing primer targets enables quantitative assessment of the self-renewal and differentiation patterns of these cells in a myeloablative rhesus macaque model. Compared with other approaches to clonal tracking, this approach is highly quantitative and reproducible. We...

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PMID: 28087539
DOI: 10.1182/blood-2016-07-728691

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