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Mechanisms of blood homeostasis: lineage tracking and a neutral model of cell populations in rhesus macaques

20 Oct 2015

Abstract excerpt

BACKGROUND: How a potentially diverse population of hematopoietic stem cells (HSCs) differentiates and proliferates to supply more than 10(11) mature blood cells every day in humans remains a key biological question. We investigated this process by quantitatively analyzing the clonal structure of peripheral blood that is generated by a population of transplanted lentivirus-marked HSCs in myeloablated rhesus...

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PMID: 26486451
DOI: 10.1186/s12915-015-0191-8

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