Article

Multiomic ALS signatures highlight sex differences and molecular subclusters and identify the MAPK pathway as therapeutic target

2023-08-16

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease and lacks effective disease-modifying treatments. Here, we performed a multiomic analysis of the prefrontal cortex of 51 patients with sporadic ALS and 50 control subjects, as well as four transgenic mouse models of C9orf72-, SOD1-, TDP-43-, and FUS-ALS to characterize early and sex-specific disease mechanisms in ALS. Integrated analyses o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f7ef802b-82b2-5c94-aff2-98d113538f01
DOI: 10.1101/2023.08.14.553180

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multiomic ALS signatures highlight sex differences and molecular subclusters and identify the MAPK pathway as therapeutic targetDOI 10.1101/2023.08.14.553180Read

Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic targetSemantic proximity Read

Redefining ALS: Large-scale proteomic profiling reveals a prolonged pre-diagnostic phase with immune, muscular, metabolic, and brain involvementSemantic proximity Read

Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvementSemantic proximity Read

Multi-regional transcriptomic profiling reveals divergent molecular mechanisms in ALS-related neurodegeneration.Semantic proximity Read

Transcriptomics Analyses of ALS Post-mortem Motor Cortex highlight alteration and potential biomarkers in the Neuropeptide Signalling pathwaySemantic proximity Read

A mitochondrial-immune axis drives the transcriptomic transition from brain aging to Alzheimer’s diseaseSemantic proximity Read

Integrative Profiling of Amyotrophic Lateral Sclerosis Lymphoblasts Identifies Unique Metabolic and Mitochondrial Disease Fingerprints.Semantic proximity Read

Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALSSemantic proximity Read

Network Analysis of the Cerebrospinal Fluid Proteome Reveals Shared and Unique Differences Between Sporadic and Familial Forms of Amyotrophic Lateral SclerosisSemantic proximity Read

Gene Expression Profiles in Sporadic ALS Fibroblasts Define Disease Subtypes and The Metabolic Effects of the Investigational Drug EH301Semantic proximity Read

Proteome Homeostasis Dysfunction: A Unifying Principle in ALS PathogenesisSemantic proximity Read