Multi-regional transcriptomic profiling reveals divergent molecular mechanisms in ALS-related neurodegeneration.

Abstract excerpt

Neurodegenerative disorders including amyotrophic lateral sclerosis (ALS) remain largely unsolved, with complex etiology yet to be fully elucidated. The most common genetic cause of ALS in both familial and sporadic cases is the expansion of a hexanucleotide repeat in the C9orf72 gene. To systematically dissect the molecular landscape of ALS, we performed integrative transcriptomic analyses across multiple...

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• C9orf72 Protein
• Amyotrophic Lateral Sclerosis
• DNA Repeat Expansion
• Gene Expression Profiling
• Mutation