Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrative Profiling of Amyotrophic Lateral Sclerosis Lymphoblasts Identifies Unique Metabolic and Mitochondrial Disease Fingerprints.

Molecular neurobiology - 1 Oct 2022

Cunha-Oliveira Teresa, Carvalho Marcelo, Sardão Vilma, Ferreiro Elisabete, Mena Débora, Pereira Francisco B, Borges Fernanda, Oliveira Paulo J, Silva Filomena S G

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with a rapid progression and no effective treatment. Metabolic and mitochondrial alterations in peripheral tissues of ALS patients may present diagnostic and therapeutic interest. We aimed to identify mitochondrial fingerprints in lymphoblast from ALS patients harboring SOD1 mutations (mutSOD1) or with unidentified mutations (undSOD1),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Amyotrophic Lateral Sclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bayes Theorem

Share to Mitochondrial Diseases

Share to Mutation

Share to Neurodegenerative Diseases

Share to Superoxide Dismutase

Share to Superoxide Dismutase-1

Source

Identifiers

PMID: 35933467
DOI: 10.1007/s12035-022-02980-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrative Profiling of Amyotrophic Lateral Sclerosis Lymphoblasts Identifies Unique Metabolic and Mitochondrial Disease Fingerprints.PMID 35933467Read ↗

Integrative Profiling of Amyotrophic Lateral Sclerosis Lymphoblasts Identifies Unique Metabolic and Mitochondrial Disease FingerprintsSemantic proximity Read ↗

Oxidative stress profiles of lymphoblasts from Amyotrophic Lateral Sclerosis patients with or without known SOD1 mutationsSemantic proximity Read ↗

Redox profiles of amyotrophic lateral sclerosis lymphoblasts with or without known SOD1 mutations.Semantic proximity Read ↗

Integrated Multi-Omic Data Analysis and Validation with Yeast Model Show Oxidative Phosphorylation Modulate Protein Aggregation in Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Multiomic ALS signatures highlight sex differences and molecular subclusters and identify the MAPK pathway as therapeutic targetSemantic proximity Read ↗

Gene Expression Profiles in Sporadic ALS Fibroblasts Define Disease Subtypes and The Metabolic Effects of the Investigational Drug EH301Semantic proximity Read ↗

Mechanistic Insights of Mitochondrial Dysfunction in Amyotrophic Lateral Sclerosis: An Update on a Lasting RelationshipSemantic proximity Read ↗

Molecular Alterations in Sporadic and SOD1-ALS Immortalized Lymphocytes: Towards a Personalized Therapy.Semantic proximity Read ↗

Metabolomics: A Tool to Understand the Impact of Genetic Mutations in Amyotrophic Lateral Sclerosis.Semantic proximity Read ↗

Identification of a Distinct Metabolomic Subtype of Sporadic ALS PatientsSemantic proximity Read ↗

Mitochondrial and energy metabolism dysfunctions are hallmarks of TDP-43G376D fibroblasts from members of an Amyotrophic Lateral Sclerosis familySemantic proximity Read ↗

Redefining ALS: Large-scale proteomic profiling reveals a prolonged pre-diagnostic phase with immune, muscular, metabolic, and brain involvementSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.