Article

A global overview of single-cell type selectivity and pleiotropy in complex diseases and traits

2020-11-20

Abstract excerpt

After centuries of genetic studies, one of the most fundamental questions, i.e. in what cell types do DNA mutations regulate a phenotype, remains unanswered for most complex phenotypes. The current availability of hundreds of genome-wide association studies (GWASs) and single-cell RNA sequencing (scRNA-seq) of millions of cells provides a unique opportunity to address the question. In the present study, we firstly...

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Literature Corpus work: f7ef20ee-9619-5425-a517-01aa40ae3922
DOI: 10.1101/2020.11.18.388488

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