Article

Maturation of human intestinal epithelium from pluripotency <i>in vitro</i>

2021-09-24

Abstract excerpt

Methods to generate human intestinal tissue from pluripotent stem cells (PSCs) open new inroads into modeling intestine development and disease. However, current protocols require organoid transplantation into an immunocompromised mouse to achieve matured and differentiated epithelial cell states. Inspired by developmental reconstructions from primary tissues, we establish a regimen of inductive cues that enable s...

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Literature Corpus work: 557d0b0a-f225-5fd4-a874-0cd6b2b04652
DOI: 10.1101/2021.09.24.460132

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