Back to search

Article

An intragenic duplication within<i>SIRPβ1</i>shows a dual effect over Alzheimer’s disease cognitive decline altering the microglial response

2022-11-20

Abstract excerpt

Microglia play an important role in the maintenance of brain homeostasis, and microglial dysfunction plays a causative role in Alzheimer disease pathogenesis. Here we focus on the signal regulatory protein SIRPβ1, a surface receptor expressed on the myeloid cells that triggers amyloid-β and cell debris phagocytosis via TYROBP. We found that a common intragenic duplication alters the SIRPβ1 protein isoform landscap...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f7da7039-5a2f-5853-b437-60637db206b6
DOI
10.1101/2022.11.19.22282342
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
An intragenic duplication within<i>SIRPβ1</i>shows a dual effect over Alzheimer’s disease cognitive decline altering the microglial responseDOI 10.1101/2022.11.19.22282342
Monoallelic<i>TYROBP</i>deletion is a novel risk factor for Alzheimer’s diseaseSemantic proximity
Monoallelic TYROBP deletion is a novel risk factor for Alzheimer's disease.Semantic proximity
TREM2 R47H exacerbates immune response in Alzheimer’s disease brainSemantic proximity
Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer's Disease Brain.Semantic proximity
A microglia clonal inflammatory disorder in Alzheimer's disease.Semantic proximity
TREM2 variants that cause early dementia and increase Alzheimer's disease risk affect gene splicing.Semantic proximity
A microglia clonal inflammatory disorder in Alzheimer’s DiseaseSemantic proximity
­TREM2-H157Y Increases Soluble TREM2 Production and Reduces Amyloid PathologySemantic proximity
TREM2-H157Y Increases Soluble TREM2 Production and Reduces Amyloid PathologySemantic proximity
The <i>MS4A</i> gene cluster is a key regulator of soluble TREM2 and Alzheimer disease riskSemantic proximity
<i>TREM2</i>Risk Variants with Alzheimer’s Disease Differ in Rate of Cognitive DeclineSemantic proximity
The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.Semantic proximity
Select a neighboring publication to make it the new centre.