Article

Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice

2020-12-16

Abstract excerpt

Prime editors (PEs) mediate genome modification without utilizing double-stranded DNA breaks or exogenous donor DNA as a template. PEs facilitate nucleotide substitutions or local insertions or deletions within the genome based on the template sequence encoded within the prime editing guide RNA (pegRNA). However, the efficacy of prime editing in adult mice has not been established. Here we report an NLS-optimized...

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Literature Corpus work: f7cadd77-a93d-5f6a-86dc-ade3d84a327a
DOI: 10.1101/2020.12.15.422970

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