Article

Prime editing enables precise genome editing in mouse liver and retina

2021-01-08

Abstract excerpt

Prime editing can induce any small-sized genetic change without donor DNA or double strand breaks. However, it has not been investigated whether prime editing is possible in postnatal animals. Here we delivered prime editors 2 and 3 into a mouse model of hereditary tyrosinemia, a genetic liver disease, using hydrodynamic injection, which corrected the disease-causing mutation and rescued the phenotype. We also ach...

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Literature Corpus work: d78e8b07-1f2b-5fef-9da9-6dd140b5b2e3
DOI: 10.1101/2021.01.08.425835

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