Article

Generation and characterization of a mouse model of conditional <i>Chd4</i> knockout in the endometrial epithelium

2025-06-09

Abstract excerpt

Chromatin remodeling plays an integral part in endometrial homeostasis, having roles in the maintenance of cell identity, epithelial integrity, and prevention of endometrial disease. Chromodomain-helicase-DNA-binding protein 4 ( CHD4 ) is a chromatin remodeling protein and member of the NuRD complex, which predominantly represses transcription. CHD4 is mutated in endometrial carcinoma, with most mutations leadin...

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Literature Corpus work: f7c5ad17-0e4d-55ae-828e-722c615fd3ee
DOI: 10.1101/2025.06.05.658183

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