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Article

SWI/SNF inactivation in the endometrial epithelium leads to loss of epithelial integrity.

Human molecular genetics - 18 Dec 2020

Reske Jake J, Wilson Mike R, Holladay Jeanne, Wegener Marc, Adams Marie, Chandler Ronald L

Abstract excerpt

Although ARID1A mutations are a hallmark feature, mutations in other SWI/SNF (SWItch/Sucrose Non-Fermentable) chromatin remodeling subunits are also observed in endometrial neoplasms. Here, we interrogated the roles of Brahma/SWI2-related gene 1 (BRG1, SMARCA4), the SWI/SNF catalytic subunit, in the endometrial epithelium. BRG1 loss affects more than one-third of all active genes and highly overlaps with the...

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Identifiers

PMID: 33075803
DOI: 10.1093/hmg/ddaa227
PMCID: PMC7749707

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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