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Article

A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin.

Cell reports - 20 Feb 2018

Kreienkamp Ray, Graziano Simona, Coll-Bonfill Nuria, Bedia-Diaz Gonzalo, Cybulla Emily, Vindigni Alessandro, Dorsett Dale, Kubben Nard, Batista Luis Francisco Zirnberger, Gonzalo Susana

Abstract excerpt

Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease caused by a truncated lamin A protein (progerin) that drives cellular and organismal decline. HGPS patient-derived fibroblasts accumulate genomic instability, but its underlying mechanisms and contribution to disease remain poorly understood. Here, we show that progerin-induced replication stress (RS) drives genomic instability by eliciting...

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Identifiers

PMID: 29466729
DOI: 10.1016/j.celrep.2018.01.090
PMCID: PMC5848491

Genes

STAT1

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