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Article

Temporal autoregulation during human PU.1 locus SubTAD formation

12 Oct 2018

Abstract excerpt

Epigenetic control of gene expression occurs within discrete spatial chromosomal units called topologically associating domains (TADs), but the exact spatial requirements of most genes are unknown; this is of particular interest for genes involved in cancer. We therefore applied high-resolution chromosomal conformation capture sequencing to map the three-dimensional (3D) organization of the human locus encoding...

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PMID: 30315124
DOI: 10.1182/blood-2018-02-834721

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