Article

A trans-eQTL network regulates osteoclast multinucleation and bone mass

2020-02-13

Abstract excerpt

Functional characterisation of cell-type specific regulatory networks is key to establish a causal link between genetic variation and phenotype. The osteoclast offers a unique model for interrogating the contribution of co-regulated genes to in vivo phenotype as its multinucleation and resorption activities determine quantifiable skeletal traits. Here we took advantage of a trans -regulated gene network (MMnet,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f754b98d-410e-5b3b-8410-efe5d78f2122
DOI: 10.1101/2020.02.13.947705

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A trans-eQTL network regulates osteoclast multinucleation and bone massDOI 10.1101/2020.02.13.947705Read

Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclastsSemantic proximity Read

Identification of a Core Module for Bone Mineral Density through the Integration of a Co-expression Network and GWAS DataSemantic proximity Read

Leveraging osteoclast genetic regulatory data to identify genes with a role in osteoarthritis.Semantic proximity Read

Osteocyte Transcriptome Mapping Identifies a Molecular Landscape Controlling Skeletal Homeostasis and Susceptibility to Skeletal DiseaseSemantic proximity Read

Identification of a core module for bone mineral density through the integration of a co-expression network and GWAS dataSemantic proximity Read

Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis.Semantic proximity Read

Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal diseaseSemantic proximity Read

A Roadmap to Gene Discoveries and Novel Therapies in Monogenic Low and High Bone Mass Disorders.Semantic proximity Read

Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK BiobankSemantic proximity Read

Perspective of the GEMSTONE Consortium on Current and Future Approaches to Functional Validation for Skeletal Genetic Disease Using Cellular, Molecular and Animal-Modeling Techniques.Semantic proximity Read

Identification of Differentially Expressed Genes and Molecular Pathways Involved in Osteoclastogenesis Using RNA-seqSemantic proximity Read

Shared Genetic Architecture between Muscle and Bone: Identification and Functional Implications of <i>EPDR1</i> , <i>PKDCC</i> , and <i>SPTBN1</i>Semantic proximity Read