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Article

Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts

26 Mar 2020

Abstract excerpt

BACKGROUND: Osteoporosis is a complex disease with a strong genetic contribution. A recently published genome-wide association study (GWAS) for estimated bone mineral density (eBMD) identified 1103 independent genome-wide significant association signals. Most of these variants are non-coding, suggesting that regulatory effects may drive many of the associations. To identify genes with a role in osteoporosis, we...

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PMID: 32216834
DOI: 10.1186/s13059-020-01997-2

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