Article

Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease

2024-12-17

Abstract excerpt

Musculoskeletal diseases are a major health burden. Development of bone-active therapies has been hindered by limited understanding of the cells and genes that regulate the skeleton. We exploited the value of cross-species analysis and developed single-cell methodologies in skeletal tissues to define the critical endosteal compartment that regulates bone turnover. Thirty-four distinct cell types were identified, a...

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Literature Corpus work: b6581e82-c458-5a7d-8348-31b3aeac4995
DOI: 10.1101/2024.12.16.628792

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