Article
Leveraging osteoclast genetic regulatory data to identify genes with a role in osteoarthritis.
Genetics - 4 Oct 2023
Mullin Benjamin H, Zhu Kun, Brown Suzanne J, Mullin Shelby, Dudbridge Frank, Pavlos Nathan J, Richards J Brent, Grundberg Elin, Bell Jordana T, Zeggini Eleftheria, Walsh John P, Xu Jiake, Wilson Scott G
Abstract excerpt
There has been a growing interest in the role of the subchondral bone and its resident osteoclasts in the progression of osteoarthritis (OA). A recent genome-wide association study (GWAS) identified 100 independent association signals for OA traits. Most of these signals are led by noncoding variants, suggesting that genetic regulatory effects may drive many of the associations. We have generated a unique human...
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