Article

Osteocyte Transcriptome Mapping Identifies a Molecular Landscape Controlling Skeletal Homeostasis and Susceptibility to Skeletal Disease

2020-04-22

Abstract excerpt

Osteocytes are master regulators of the skeleton. We mapped the transcriptome of osteocytes from different skeletal sites, across age and sexes in mice to reveal genes and molecular programs that control this complex cellular-network. We define an osteocyte transcriptome signature of 1239 genes that distinguishes osteocytes from other cells. 77% have no previously known role in the skeleton and are enriched for g...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 196e8fbd-4750-55dc-b87d-3a39c650e9aa
DOI: 10.1101/2020.04.20.051409

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Osteocyte Transcriptome Mapping Identifies a Molecular Landscape Controlling Skeletal Homeostasis and Susceptibility to Skeletal DiseaseDOI 10.1101/2020.04.20.051409Read

The Osteocyte Transcriptome Is Extensively Dysregulated in Mouse Models of Osteogenesis ImperfectaSemantic proximity Read

Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal diseaseSemantic proximity Read

Cell type-specific network analysis in Diversity Outbred mice identifies genes potentially responsible for human bone mineral density GWAS associationsSemantic proximity Read

The transcriptome of regenerating zebrafish scales identifies genes involved in human bone diseaseSemantic proximity Read

Control of osteocyte dendrite formation by Sp7 and its target gene osteocrinSemantic proximity Read

Evaluation of a scalable approach to generate cell-type specific transcriptomic profiles of mesenchymal lineage cellsSemantic proximity Read

Spatial transcriptomic interrogation of the murine bone marrow signaling landscapeSemantic proximity Read

A trans-eQTL network regulates osteoclast multinucleation and bone massSemantic proximity Read

Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin.Semantic proximity Read

Single-Cell RNA-Sequencing Reveals the Skeletal Cellular Dynamics in Bone Repair and OsteoporosisSemantic proximity Read

Single cell transcriptomics identifies a unique adipocyte population that regulates bone marrow environmentSemantic proximity Read

Single‐Cell Transcriptomics of Bone Marrow Stromal Cells in Diversity Outbred Mice: A Model for Population‐Level scRNA ‐Seq StudiesSemantic proximity Read