Article

Dissecting the DNA damage response : structural and biochemical insights into the Mec1-Ddc2 checkpoint kinase complex

2017-01-01

Abstract excerpt

The survival and proper functioning of an organism depends on the faithful replication of its genetic material. The yeast checkpoint kinase Mec1 and its integral partner Ddc2 (human ATR and ATRIP respectively) play a pivotal role in initiating checkpoint signalling as a response to DNA damage. Mec1 is activated by cell cycle speci c activators that act through conserved aromatic residues located in their unstructu...

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Literature Corpus work: f7473d68-6f72-5b8f-b6ae-8f1860b13607
DOI: 10.25560/45289

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