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Article

CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response.

Nucleic acids research - 1 Mar 2010

Becherel Olivier J, Jakob Burkhard, Cherry Amy L, Gueven Nuri, Fusser Markus, Kijas Amanda W, Peng Cheng, Katyal Sachin, McKinnon Peter J, Chen Junjie, Epe Bernd, Smerdon Stephen J, Taucher-Scholz Gisela, Lavin Martin F

Abstract excerpt

Aprataxin, defective in the neurodegenerative disorder ataxia oculomotor apraxia type 1, resolves abortive DNA ligation intermediates during DNA repair. Here, we demonstrate that aprataxin localizes at sites of DNA damage induced by high LET radiation and binds to mediator of DNA-damage checkpoin...

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Identifiers

PMID: 20008512
DOI: 10.1093/nar/gkp1149
PMCID: PMC2836575

Genes

MDC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20008512-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response.PMID 20008512Read ↗

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