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The complex matter of DNA double-strand break detection

1 Feb 2003

Abstract excerpt

To maintain genomic stability, despite constant exposure to agents that damage DNA, eukaryotic cells have developed elaborate and highly conserved pathways of DNA damage sensing, signalling and repair. In this review, we concentrate mainly on what we know about DNA damage sensing with particular reference to Lcd1p, a yeast protein that functions early in DNA damage signalling, and MDC1 (mediator of DNA damage...

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PMID: 12546650
DOI: 10.1042/bst0310040

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