Article

High regeneration-associated stress defines a distinct HCC subgroup with therapeutically exploitable vulnerabilities

2026-08-20

Abstract excerpt

<h4>Background</h4> To date, no precision oncology approach has been established for HCC. Despite the diverse underlying causes, HCC development exhibits a uniform pathophysiology characterised by chronic hyper-proliferation, resulting from hepatocyte apoptosis and compensatory liver regeneration. This chronic hyper-proliferative pressure, termed “regeneration stress”, drives genomic instability during HCC onset,...

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Literature Corpus work: f7324ff3-c3a2-52c0-a8c4-5b032078a7e1
DOI: 10.64898/2026.08.19.745832

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