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Comprehensive multi-omics analyses expose a precision therapy strategy that targets replication stress in hepatocellular carcinoma using WEE1 inhibition

18 Feb 2025

Abstract excerpt

INTRODUCTION: Hepatocellular carcinoma (HCC) is an extremely heterogeneous malignancy with a poor prognosis, highlighting the need to target specific vulnerabilities within the tumor during treatment. OBJECTIVES: This study employs multi-omics analysis techniques to provide novel insights into personalized therapeutic strategies for HCC patients. METHODS: We performed proteomic and transcriptomic sequencing on...

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PMID: 39978541
DOI: 10.1016/j.jare.2025.02.016

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