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Article

Pharmacogenomic profiling of intra-tumor heterogeneity using a large organoid biobank of liver cancer

1 Apr 2024

Abstract excerpt

Inter- and intra-tumor heterogeneity is a major hurdle in primary liver cancer (PLC) precision therapy. Here, we establish a PLC biobank, consisting of 399 tumor organoids derived from 144 patients, which recapitulates histopathology and genomic landscape of parental tumors, and is reliable for drug sensitivity screening, as evidenced by both in vivo models and patient response. Integrative analysis dissects PLC...

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PMID: 38593780
DOI: 10.1016/j.ccell.2024.03.004

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