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DNA replication stress stratifies prognosis and enables exploitable therapeutic vulnerabilities of HBV-associated hepatocellular carcinoma: an <i>in silico</i> strategy towards precision oncology

2021-09-06

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Hepatitis B virus (HBV), the main risk factor for hepatocellular carcinoma (HCC) development, integrates into the host genome, causing genetic instability, which may trigger malignancies to exhibit chronic DNA replication stress, providing exploitable therapeutic vulnerabilities. Therefore, customizing prognostication approach and expanding therapeutic options are of great c...

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Literature Corpus work
6bd51e60-aee7-551f-9b83-6b8209a61d01
DOI
10.1101/2021.09.04.458962
Open publication

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