Article

Targeted Transcriptome Analysis using Synthetic Long Read Sequencing Uncovers Isoform Reprograming in the Progression of Colon Cancer

2020-08-07

Abstract excerpt

Diversity in human gene expression stems, to a large extent, from splicing exons into multiple mRNA isoforms. Characterization of isoforms requires accurate long-read sequencing. However, read lengths, high error rates, low throughput and large input requirements are some of the challenges that remain to be addressed in sequencing technologies. In this study, we used a barcoding-based synthetic long read (SLR) iso...

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Literature Corpus work: f72e11d2-e1f1-52a5-a934-c415d3ec6d4f
DOI: 10.1101/2020.08.07.240069

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