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Acute Myeloid Leukemia Driven by the CALM-AF10 Fusion Gene is Dependent on BMI1

2019-01-18

Abstract excerpt

<h4>ABSTRACT</h4> A subset of acute myeloid and lymphoid leukemia cases harbor a t(10;11)(p13;q14) translocation resulting in the CALM-AF10 fusion gene. Standard chemotherapeutic strategies are often ineffective in treating patients with CALM-AF10 fusions. Hence, there is an urgent need to identify molecular pathways dysregulated in CALM-AF10-positive leukemias which may lay the foundation for novel targeted ther...

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Literature Corpus work
f729768b-278e-5a04-b5ce-1b984302348e
DOI
10.1101/524066
Open publication

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Acute Myeloid Leukemia Driven by the CALM-AF10 Fusion Gene is Dependent on BMI1DOI 10.1101/524066
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