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Article

The polycomb group BMI1 gene is a molecular marker for predicting prognosis of chronic myeloid leukemia

14 Mar 2007

Abstract excerpt

Because the polycomb group gene BMI1 regulates the proliferation of both normal and leukemic stem cells, we examined whether BMI1 expression was associated with disease progression in chronic myeloid leukemia (CML). Levels of BMI1 RNA were significantly higher in patients with advanced-phase than in patients with chronic-phase CML in both CD34(+) cells (P = .006) and total peripheral-blood mononuclear cells (P <...

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PMID: 17360938
DOI: 10.1182/blood-2006-12-065599

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