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Article

The clathrin-binding domain of CALM-AF10 alters the phenotype of myeloid neoplasms in mice.

Oncogene - 26 Jan 2012

Stoddart A, Tennant T R, Fernald A A, Anastasi J, Brodsky F M, Le Beau M M

Abstract excerpt

The PICALM (CALM) gene, whose product is involved in clathrin-mediated endocytosis, has been identified in two recurring chromosomal translocations, involving either MLL or MLLT10 (AF10). We developed a mouse model of CALM-AF10(+) leukemia to examine the hypothesis that disruption of endocytosis contributes to leukemogenesis. Exclusion of the C-terminal portion of CALM from the fusion protein, which is required...

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Topics

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Share to Clathrin
Share to Endocytosis
Share to Histones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Oncogene Proteins, Fusion

Share to Protein Multimerization

Share to Proto-Oncogene Proteins c-kit

Share to Receptors, Growth Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 21706055
DOI: 10.1038/onc.2011.251
PMCID: PMC3204175

Genes

MLLT10
PICALM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The clathrin-binding domain of CALM-AF10 alters the phenotype of myeloid neoplasms in mice.PMID 21706055Read ↗

The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice.Semantic proximity Read ↗

A CALM-derived nuclear export signal is essential for CALM-AF10–mediated leukemogenesisSemantic proximity Read ↗

Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology.Semantic proximity Read ↗

Molecular analysis of the CALM/AF10 fusion: identical rearrangements in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma patientsSemantic proximity Read ↗

Uncoupling the functions of CALM in VAMP sorting and clathrin-coated pit formation.Semantic proximity Read ↗

MLL and CALM are fused to AF10 in morphologically distinct subsets of acute leukemia with translocation t(10;11): both rearrangements are associated with a poor prognosis.Semantic proximity Read ↗

Mutations in the clathrin-assembly gene Picalm are responsible for the hematopoietic and iron metabolism abnormalities in fit1 mice.Semantic proximity Read ↗

Acute Myeloid Leukemia Driven by the CALM-AF10 Fusion Gene is Dependent on BMI1Semantic proximity Read ↗

A Novel Sequence in AP180 and CALM Promotes Efficient Clathrin Binding and Assembly.Semantic proximity Read ↗

Expression of a <i>CALM-AF10</i> Fusion Gene Leads to <i>Hoxa</i> Cluster Overexpression and Acute Leukemia in Transgenic MiceSemantic proximity Read ↗

The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models.Semantic proximity Read ↗

Retroviral insertional mutagenesis identifies Zeb2 activation as a novel leukemogenic collaborating event in CALM-AF10 transgenic mice.Semantic proximity Read ↗

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