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Article

The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models.

Leukemia - 1 May 2016

Dutta S, Krause A, Vosberg S, Herold T, Ksienzyk B, Quintanilla-Martinez L, Tizazu B, Chopra M, Graf A, Krebs S, Blum H, Greif P A, Vetter A, Metzeler K, Rothenberg-Thurley M, Schneider M R, Dahlhoff M, Spiekermann K, Zimber-Strobl U, Wolf E, Bohlander S K

Abstract excerpt

The CALM/AF10 fusion gene is found in various hematological malignancies including acute myeloid leukemia (AML), T-cell acute lymphoblastic leukemia and malignant lymphoma. We have previously identified the leukemia stem cell (LSC) in a CALM/AF10-driven murine bone marrow transplant AML model as B220+ lymphoid cells with B-cell characteristics. To identify the target cell for leukemic transformation or 'cell of...

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Share to B-Lymphocytes
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Experimental

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Share to Oncogene Proteins, Fusion

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Source

Identifiers

PMID: 26686248
DOI: 10.1038/leu.2015.349

Genes

FLT3
PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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