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Article

A CALM-derived nuclear export signal is essential for CALM-AF10–mediated leukemogenesis

14 Mar 2013

Abstract excerpt

The t(10;11) chromosomal translocation gives rise to the CALM-AF10 fusion gene and is found in patients with aggressive and difficult-to-treat hematopoietic malignancies. CALM-AF10-driven leukemias are characterized by HOXA gene up-regulation and a global reduction in H3K79 methylation. DOT1L, the H3K79 methyltransferase, interacts with the octapeptide/leucine zipper domain of AF10, and this region has been shown...

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Identifiers

PMID: 23487024
DOI: 10.1182/blood-2012-06-435792

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Related research

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A CALM-derived nuclear export signal is essential for CALM-AF10–mediated leukemogenesisPMID 23487024Read ↗

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The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models.Semantic proximity Read ↗

The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10Semantic proximity Read ↗

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