Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Retroviral insertional mutagenesis identifies Zeb2 activation as a novel leukemogenic collaborating event in CALM-AF10 transgenic mice.

Blood - 11 Feb 2010

Caudell David, Harper David P, Novak Rachel L, Pierce Rachel M, Slape Christopher, Wolff Linda, Aplan Peter D

Abstract excerpt

The t(10;11) translocation results in a CALM-AF10 fusion gene in a subset of leukemia patients. Expression of a CALM-AF10 transgene results in leukemia, with prolonged latency and incomplete penetrance, suggesting that additional events are necessary for leukemic transformation. CALM-AF10 mice in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immunophenotyping
Share to Leukemia, B-Cell
Share to Leukemia, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oncogene Proteins, Fusion

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to ras Proteins

Share to Retroviridae

Share to Zinc Finger E-box Binding Homeobox 2

Source

Open in PubMed Open full text

Identifiers

PMID: 20007546
DOI: 10.1182/blood-2009-04-216184
PMCID: PMC2826231

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20007546-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Retroviral insertional mutagenesis identifies Zeb2 activation as a novel leukemogenic collaborating event in CALM-AF10 transgenic mice.PMID 20007546Read ↗

A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AMLSemantic proximity Read ↗

Gene expression profiling and candidate gene resequencing identifies pathways and mutations important for malignant transformation caused by leukemogenic fusion genes.Semantic proximity Read ↗

A JAK/STAT-Mediated Inflammatory Signaling Cascade Drives Oncogenesis In AF10-Rearranged AMLSemantic proximity Read ↗

A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor geneSemantic proximity Read ↗

Molecular analysis of the CALM/AF10 fusion: identical rearrangements in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma patientsSemantic proximity Read ↗

The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models.Semantic proximity Read ↗

Expression of a <i>CALM-AF10</i> Fusion Gene Leads to <i>Hoxa</i> Cluster Overexpression and Acute Leukemia in Transgenic MiceSemantic proximity Read ↗

Large-Scale Identification of Disease Genes Involved in Acute Myeloid LeukemiaSemantic proximity Read ↗

The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10Semantic proximity Read ↗

A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression.Semantic proximity Read ↗

Altered NFE2 activity predisposes to leukemic transformation and myelosarcoma with AML-specific aberrationsSemantic proximity Read ↗

PAX5-ELN oncoprotein promotes multistep B-cell acute lymphoblastic leukemia in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.