Article

Identification of SUMO targets required to maintain human stem cells in the pluripotent state

2020-12-22

Abstract excerpt

To determine the role of SUMO modification in the maintenance of pluripotent stem cells we used ML792, a potent and selective inhibitor of SUMO Activating Enzyme. Treatment of human induced pluripotent stem cells with ML792 initiated changes associated with loss of pluripotency such as reduced expression of key pluripotency markers. To identify putative effector proteins and establish sites of SUMO modification, c...

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Literature Corpus work: f71e82d3-7fd6-549a-b4ef-90a7817ef01b
DOI: 10.1101/2020.12.22.423944

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