Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity.

PloS one - 2 Mar 2010

Marongiu Mara, Deiana Manila, Meloni Alessandra, Marcia Loredana, Puddu Alessandro, Cao Antonio, Schlessinger David, Crisponi Laura

Abstract excerpt

The FOXL2 forkhead transcription factor is expressed in ovarian granulosa cells, and mutated FOXL2 causes the blepharophimosis, ptosis and epicanthus inversus syndrome (BPES) and predisposes to premature ovarian failure. Inactivation of Foxl2 in mice demonstrated its indispensability for female gonadal sex determination and ovary development and revealed its antagonism of Sox9, the effector of male testis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops
Share to COS Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Box Protein L2

Share to Forkhead Transcription Factors

Share to Gene Expression Profiling

Share to SUMO-1 Protein

Share to Ubiquitin-Conjugating Enzyme UBC9

Share to Ubiquitin-Conjugating Enzymes

Source

Open in PubMed Open full text

Identifiers

PMID: 20209145
DOI: 10.1371/journal.pone.0009477
PMCID: PMC2830456

Genes

FOXL2
PIAS1
SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity.PMID 20209145Read ↗

The Genetics and Biology of FOXL2.Semantic proximity Read ↗

The transcription factor FOXL2: at the crossroads of ovarian physiology and pathology.Semantic proximity Read ↗

The mutations and potential targets of the forkhead transcription factor FOXL2.Semantic proximity Read ↗

Sumoylation: a regulatory protein modification in health and disease.Semantic proximity Read ↗

RNF4—A Paradigm for SUMOylation‐Mediated UbiquitinationSemantic proximity Read ↗

FOXL2 Interacts with Steroidogenic Factor-1 (SF-1) and Represses SF-1-Induced CYP17 Transcription in Granulosa CellsSemantic proximity Read ↗

FOXL2 interaction with different binding partners regulates the dynamics of ovarian developmentSemantic proximity Read ↗

FOXL2 interaction with different binding partners regulates the dynamics of ovarian developmentSemantic proximity Read ↗

Potential targets of FOXL2, a transcription factor involved in craniofacial and follicular development, identified by transcriptomicsSemantic proximity Read ↗

LATS1 phosphorylates forkhead L2 and regulates its transcriptional activitySemantic proximity Read ↗

The post-translational modification, SUMOylation, and cancer (Review)Semantic proximity Read ↗

FOXL2 Is an Essential Activator of SF-1-Induced Transcriptional Regulation of Anti-Müllerian Hormone in Human Granulosa Cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.