Article

Non-canonical Sodium Channel Isoforms Underlie Chamber Specific Cardiac Excitability

2025-09-01

Abstract excerpt

Voltage-gated sodium (Na V ) channels drive cardiac excitability. While Na V 1.5 is the primary cardiac isoform, the composition and functional contributions of non-Na V 1.5 isoforms in the heart remain unclear. Here, we developed a chemical-genetic mouse model (Na V 1.5-GX) in which Na V 1.5 can be selectively and reversibly inhibited by acyl- and aryl-sulfonamide compounds (GX drugs). Na V 1.5-GX mice exhi...

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Literature Corpus work: bd6e7079-875f-5c6f-8250-04beb74c698a
DOI: 10.1101/2025.08.27.672688

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