Article

A chemogenetic ligand-receptor pair for voltage-gated sodium channel subtype-selective inhibition

2025-11-05

Abstract excerpt

<h4>ABSTRACT</h4> Neuronal excitability relies on the tightly regulated expression and discrete subcellular localization of voltage-gated sodium channels (Na V s). These large membrane protein complexes control the movement of sodium ions across cell membranes and are responsible for initiating and propagating action potentials. A desire to better understand the role of Na V subtypes in electrical signal conduc...

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Literature Corpus work: 81c1b4af-24f8-5fdf-8c5c-fc743b2cdcad
DOI: 10.1101/2025.11.03.686046

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