Article
A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias.
The Journal of pharmacology and experimental therapeutics - 1 Jan 2013
Belardinelli Luiz, Liu Gongxin, Smith-Maxwell Cathy, Wang Wei-Qun, El-Bizri Nesrine, Hirakawa Ryoko, Karpinski Serge, Li Cindy Hong, Hu Lufei, Li Xiao-Jun, Crumb William, Wu Lin, Koltun Dmitry, Zablocki Jeff, Yao Lina, Dhalla Arvinder K, Rajamani Sridharan, Shryock John C
Abstract excerpt
Inhibition of cardiac late sodium current (late I(Na)) is a strategy to suppress arrhythmias and sodium-dependent calcium overload associated with myocardial ischemia and heart failure. Current inhibitors of late I(Na) are unselective and can be proarrhythmic. This study introduces GS967 (6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine), a potent and selective inhibitor of late...
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