Article

Late cardiac sodium current can be assessed using automated patch-clamp

2014-10-16

Abstract excerpt

The cardiac late Na + current is generated by a small fraction of voltage-dependent Na + channels that undergo a conformational change to a burst-gating mode, with repeated openings and closures during the action potential (AP) plateau. Its magnitude can be augmented by inactivation-defective mutations, myocardial ischemia, or prolonged exposure to chemical compounds leading to drug-induced (di)-long QT syndrome...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 978cb0ae-458e-5e97-b5fe-cf350852219a
DOI: 10.12688/f1000research.5544.1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Late cardiac sodium current can be assessed using automated patch-clampDOI 10.12688/f1000research.5544.1Read

The role of late I Na in development of cardiac arrhythmias.Semantic proximity Read

The efficacy of Ranolazine on E1784K is altered by temperature and calcium.Semantic proximity Read

Late I <sub>Na</sub> activation of cardiac TTX-sensitive sodium channels by AaH-II induces an arrhythmogenic phenotypeSemantic proximity Read

Absence of Functional Nav1.8 Channels in Non-diseased Atrial and Ventricular CardiomyocytesSemantic proximity Read

Persistent human cardiac Na+ currents in stably transfected mammalian cells: Robust expression and distinct open-channel selectivity among Class 1 antiarrhythmics.Semantic proximity Read

Ranolazine and late cardiac sodium current--a therapeutic target for angina, arrhythmia and more?Semantic proximity Read

State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine.Semantic proximity Read

Update on the slow delayed rectifier potassium current (I(Ks)): role in modulating cardiac function.Semantic proximity Read

Late I Na Blocker GS967 Supresses Polymorphic Ventricular Tachycardia in a Transgenic Rabbit Model of Long QT Type 2Semantic proximity Read

Actions of ATX-II and other gating-modifiers on Na(+) currents in HEK-293 cells expressing WT and DeltaKPQ hNa(V) 1.5 Na(+) channels.Semantic proximity Read

State-dependent block of wild-type and inactivation-deficient Na+ channels by flecainide.Semantic proximity Read

Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening.Semantic proximity Read