Article

Oncogenic GNAS uses PKA-dependent and independent mechanisms to induce cell proliferation in human pancreatic ductal and acinar organoids

2023-01-18

Abstract excerpt

Ductal and acinar pancreatic organoids generated from human pluripotent stem cells (hPSCs) are promising models to study pancreatic diseases, including precursor lesions of pancreatic cancer. Genome sequencing studies have revealed that mutations in a G-protein (GNAS R201C ) are exclusively observed in intraductal papillary mucinous neoplasms (IPMNs), one of the most common cystic pancreatic precancerous lesions....

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Literature Corpus work: f6f71a97-e8b7-5b2d-99e4-5c346b9ada00
DOI: 10.1101/2023.01.16.524220

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