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Article

Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells.

Cell stem cell - 3 Jun 2021

Breunig Markus, Merkle Jessica, Wagner Martin, Melzer Michael K, Barth Thomas F E, Engleitner Thomas, Krumm Johannes, Wiedenmann Sandra, Cohrs Christian M, Perkhofer Lukas, Jain Gaurav, Krüger Jana, Hermann Patrick C, Schmid Maximilian, Madácsy Tamara, Varga Árpád, Griger Joscha, Azoitei Ninel, Müller Martin, Wessely Oliver, Robey Pamela G, Heller Sandra, Dantes Zahra, Reichert Maximilian, Günes Cagatay, Bolenz Christian, Kuhn Florian, Maléth József, Speier Stephan, Liebau Stefan, Sipos Bence, Kuster Bernhard, Seufferlein Thomas, Rad Roland, Meier Matthias, Hohwieler Meike, Kleger Alexander

Abstract excerpt

Personalized in vitro models for dysplasia and carcinogenesis in the pancreas have been constrained by insufficient differentiation of human pluripotent stem cells (hPSCs) into the exocrine pancreatic lineage. Here, we differentiate hPSCs into pancreatic duct-like organoids (PDLOs) with morphological, transcriptional, proteomic, and functional characteristics of human pancreatic ducts, further maturing upon...

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Identifiers

PMID: 33915078
DOI: 10.1016/j.stem.2021.03.005
PMCID: PMC8461636

Genes

KRAS
CDKN2A
GNAS

Provenance

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