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Article

Oncogene addiction to GNAS in GNASR201 mutant tumors.

Oncogene - 1 Aug 2022

More Aditya, Ito Ichiaki, Haridas Valsala, Chowdhury Saikat, Gu Yue, Dickson Princess, Fowlkes Natalie, Shen John Paul

Abstract excerpt

The GNASR201 gain-of-function mutation is the single most frequent cancer-causing mutation across all heterotrimeric G proteins, driving oncogenesis in various low-grade/benign gastrointestinal and pancreatic tumors. In this study, we investigated the role of GNAS and its product Gαs in tumor progression using peritoneal models of colorectal cancer (CRC). GNAS was knocked out in multiple CRC cell lines harboring...

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PMID: 35879396
DOI: 10.1038/s41388-022-02388-6

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