Article
In silico investigation of the interaction between the voltage-gated potassium channel Kv4.3 and its auxiliary protein KChIP1.
Physical chemistry chemical physics : PCCP - 7 Dec 2019
Catte Andrea, Ferbel Letizia, Bhattacharjee Nicholus, Jan Akhunzada Muhammad, D'Agostino Tommaso, Brancato Giuseppe
Abstract excerpt
The voltage-gated potassium channel Kv4.3 plays a vital role in shaping the timing, frequency, and backpropagation of electrical signals in the brain and heart by generating fast transient currents at subthreshold membrane potentials in repetitive firing neurons. To achieve its physiological function, Kv4.3 is assisted by auxiliary β-subunits that become integral parts of the native A-type potassium channels,...
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