Article

A quantile integral linear model to quantify genetic effects on phenotypic variability

2021-04-14

Abstract excerpt

Detecting genetic variants associated with the variance of complex traits, i.e. variance quantitative trait loci (vQTL), can provide crucial insights into the interplay between genes and environments and how they jointly shape human phenotypes in the population. We propose a quantile integral linear model (QUAIL) to estimate genetic effects on trait variability. Through extensive simulations and analyses of real d...

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Literature Corpus work: f6e13a8f-2454-5c75-9eb3-a9221384994b
DOI: 10.1101/2021.04.14.439847

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