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Article

A quantile integral linear model to quantify genetic effects on phenotypic variability.

Proceedings of the National Academy of Sciences of the United States of America - 27 Sept 2022

Miao Jiacheng, Lin Yupei, Wu Yuchang, Zheng Boyan, Schmitz Lauren L, Fletcher Jason M, Lu Qiongshi

Abstract excerpt

Detecting genetic variants associated with the variance of complex traits, that is, variance quantitative trait loci (vQTLs), can provide crucial insights into the interplay between genes and environments and how they jointly shape human phenotypes in the population. We propose a quantile integral linear model (QUAIL) to estimate genetic effects on trait variability. Through extensive simulations and analyses of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36122202
DOI: 10.1073/pnas.2212959119
PMCID: PMC9522331

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