Back to search

Article

Queuosine glycosylation protects against stress-induced tRNA fragmentation and modulates cleavage site selection

2026-06-29

Abstract excerpt

Alongside their canonical function as adaptors in translation, tRNAs are precursors of tRNA-derived fragments that can regulate diverse aspects of gene expression. Queuosine (Q), present at position 34 of eukaryotic tRNA Asn/Asp/His/Tyr , has been implicated in suppressing tRNA fragmentation. In vertebrates, Q 34 of tRNA Asp and tRNA Tyr is further modified by mannosylation and galactosylation, respectively, c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f6d26ad7-9dcb-5621-b6ec-2c25d4c44e6c
DOI
10.64898/2026.06.28.735034
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Queuosine glycosylation protects against stress-induced tRNA fragmentation and modulates cleavage site selectionDOI 10.64898/2026.06.28.735034
Queuosine modification of tRNA: its divergent role in cellular machinerySemantic proximity
Queuosine modification protects cognate tRNAs against ribonuclease cleavageSemantic proximity
Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAsSemantic proximity
Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAsSemantic proximity
Biogenesis and roles of tRNA queuosine modification and its glycosylated derivatives in human health and diseasesSemantic proximity
METTL8 is required for 3-methylcytosine modification in human mitochondrial tRNAsSemantic proximity
The Biology of tRNA t6A Modification and Hypermodifications—Biogenesis and Disease RelevanceSemantic proximity
m5U54 tRNA Hypomodification by lack of TRMT2A Drives the Generation of tRNA-Derived Small RNAsSemantic proximity
m5U54 tRNA Hypomodification by Lack of TRMT2A Drives the Generation of tRNA-Derived Small RNAsSemantic proximity
tRNA modifications: greasing the wheels of translation and beyondSemantic proximity
Evolutionarily Conserved Decline of tRNA Mannosyl-Queuosine Links Translational Regulation to Aging and Is Reversed by QueuineSemantic proximity
Molecular basis for t6A modification in human mitochondria.Semantic proximity
Select a neighboring publication to make it the new centre.