Article

Novel nanopore sequencing method for determining Human Papillomavirus integrations in tumors without the need for whole genome sequencing

2024-10-19

Abstract excerpt

<h4>ABSTRACT</h4> Human papillomaviral (HPV) integrations into host human genome, a key event in cervical carcinogenesis, are currently mapped through laborious and expensive sequencing methodologies. We developed and validated a novel library preparation strategy for nanopore sequencing to generate long targeted reads with HPV and human chimeric sequences. Using this strategy, we validated known HPV integrations...

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Literature Corpus work: 6008d416-94f5-525b-88e6-305d82812899
DOI: 10.1101/2024.10.17.618842

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