Article

Structural basis for Rab8a GTPase recruitment of RILPL2 <i>via</i> LRRK2 phosphorylation of switch 2

2019-08-19

Abstract excerpt

Rab8a GTPase is associated with the dynamic regulation of membrane protrusions in polarized cells. Rab8a is one of several Rab-family GTPases that are substrates of leucine-rich repeat kinase 2 (LRRK2), a serine/threonine kinase that is linked to inherited Parkinson’s disease. Rab8a is phosphorylated at T72 (pT72) in its switch 2 helix and the post-translational modification facilitates phospho-Rab8a (pRab8a) inte...

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Literature Corpus work: 1fc32ba1-98d9-531d-ac94-202f756fa351
DOI: 10.1101/739813

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